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samples, parallel, organic, supplier, vendors, combinatorial screening libraries, chemical compounds for high throughput screening, molecular diversity screening libraries, combinatorial, high throughput screening, molecular diversity screening, combinatorial screening, chemical compounds, screening libraries, molecular screening libraries, molecular screening, library, libraries, pharmaceutical, biotechnology, consulting, GLP, cGMP, outsource, testing, logistics, management, compliance, contract, laboratory method, validation, verification, audit, analysis, bioanalysis, clinical, microbiology, training, assessment, instrumentation, start-up, failed drug rescue, event, news, achievment, prominent, outstanding Quantum Pharmaceuticals, Russia, Moscow, European, USA, Japan, Lead Optimization, Leads, Lead identification, Pharma, HIV-1, collaborations, Aids, AIDS, Cancer, Oncology, COMPLEXITY THEORY, Drug discovery Tool, Drug discovery Platform, inhibitors, integrase, ligand License, novel drug candidates, drug targets, protein, peptide, pharmacokinetic,structure based drug design, research, de-novo, innovative,biomed, life science, in silico, in vitro, in vivo, virtual Screening, fund, venture, contractor, deal, hit, non-profit, Drug-like small-molecule compounds, Acetylcholinesterase Acyl CoA- Cholesterol Acyltransferase, Intestine Acyl CoA-Cholesterol Acyltransferase, Hepatic Aldose Reductase -D- Glucosidase ATPase, Ca2+ ATPase, H+/K+ ATPase, Na+/K+ - Glucuronidase -Lactamase Carbonic Anhydrase Carnitine Palmitoyltransferase- 1 (CPT-1) Catechol-O-Methyltransferase (COMT) Choline Acetyltransferase Cyclooxygenase COX-1 Cyclooxygenase COX-2 CYP450, 19 CYP450, 1A2 CYP450, 2C19 CYP450, 2C9 CYP450, 2D6 CYP450, 3A4 Fatty Acid Amide Hydrolase (FAAH) Free Radical Scavenger, ABTS Radical Free Radical Scavenger, DPPH Radical Free Radical Scavenger, SOD Mimetic Fructose-1,6- Bisphosphatase (FBPase) Glutamate Decarboxylase Glycogen Phosphorylase Histone Deacetylase HMG- CoA Reductase Leukotriene LTA4 Hydrolase Leukotriene LTC4 Synthase Lipase Lipid Peroxidase Lipoxygenase 12- LO - New Lipoxygenase 15-LO Lipoxygenase 5-LO Monoamine Oxidase MAO-A - Improved Monoamine Oxidase MAO-B - Improved Myeloperoxidase Nitric Oxide Synthase, Endothelial (eNOS) Nitric Oxide Synthase, Inducible (iNOS) Nitric Oxide Synthase, Neuronal (nNOS) Peptidase, Angiotensin Converting Enzyme Peptidase, Calpain-1 Peptidase, Caspase 1 Peptidase, Caspase 2 Peptidase, Caspase 3 Peptidase, Caspase 4 Peptidase, Caspase 5 Peptidase, Caspase 6 Peptidase, Caspase 7 Peptidase, Caspase 8 Peptidase, Caspase 9 Peptidase, Caspase 10 Peptidase, Cathepsin B Peptidase, Cathepsin C Peptidase, Cathepsin D Peptidase, Cathepsin E Peptidase, Cathepsin G Peptidase, Cathepsin H Peptidase, Cathepsin L Peptidase, Cathepsin S Peptidase, Cathepsin V Peptidase, Chymase Peptidase, Chymotrypsin Peptidase, Dipeptidyl Peptidase IV (DPP IV) Peptidase, Endothelin Converting Enzyme-1 (ECE-1) - New Peptidase, Factor VIIa Peptidase, Factor Xa Peptidase, Kallikrein, Plasma Peptidase, Leukocyte Elastase Peptidase, Matrix Metalloproteinase-1 (MMP- 1) Peptidase, Matrix Metalloproteinase-2 (MMP-2) Peptidase, Matrix Metalloproteinase-3 (MMP-3) Peptidase, Matrix Metalloproteinase-7 (MMP-7) Peptidase, Matrix Metalloproteinase- 8 (MMP-8) Peptidase, Matrix Metalloproteinase-9 (MMP-9) Peptidase, Matrix Metalloproteinase-12 (MMP-12) - New Peptidase, Matrix Metalloproteinase-13 (MMP-13) Peptidase, Matrix Metalloproteinase-14 (MMP-14) Peptidase, Metalloproteinase, Neutral Endopeptidase Peptidase, Plasmin Peptidase, Prolyl Oligopeptidase (POP) - New Peptidase, Renin Peptidase, Thrombin Peptidase, Tissue Plasminogen Activator (tPA) Peptidase, Trypsin Peptidase, Tryptase Enzyme: Acid phosphatase Enzyme: Acyltransferase Adapter molecule Enzyme: Adenosyltransferase Adenylate cyclase Adhesion molecule Enzyme: Aldolase Enzyme: Alkaline phosphatase Aminopeptidase Enzyme: Amylase Anchor protein Aspartic protease ATPase B cell antigen receptor Calcium binding protein Enzyme: Carbonic anhydrase Enzyme: Carboxylase Carboxypeptidase Enzyme: Catalase Cell cycle control protein Cell junction protein Cell surface receptor Chaperone Chemokine Coagulation factor Complement protein Complement receptor Cysteine protease Cytokine Cytokine receptor Cytoskeletal associated protein Cytoskeletal protein Enzyme: Decarboxylase Enzyme: Deacetylase Enzyme: Deaminase Defensin Enzyme: Dehydratase Enzyme: Dehydrogenase Deoxyribonuclease DNA binding protein DNA endonuclease DNA helicase DNA ligase DNA methyltransferase DNA polymerase DNA repair protein DNA telomerase Dual specificity kinase Dual specificity phosphatase Enzyme: Epimerase Endopeptidase Enzyme regulator Enzyme: Esterase Extracellular ligand gated channel Extracellular matrix protein Enzyme: Galactosidase Enzyme: Galactosyltransferase Enzyme: Glucosaminyltransferase Enzyme: Glucosidase Enzyme: Glucuronidase Enzyme: Glutathione transferase Enzyme: Glycosidase Enzyme: Glycosylase Enzyme: Glycosyltransferase G protein G protein coupled receptor Growth factor Growth inhibitory factor GTPase GTPase activating protein Guanine nucleotide exchange factor Guanylate cyclase Enzyme: Guanyl cyclase Heat shock protein Enzyme: Hydratase Enzyme: Hydrolase Enzyme: Hydroxylase Immunoglobulin Integral membrane protein Intracellular ligand gated channel Inward rectifier channel Ion channel, other Enzyme: Isomerase Ligand Enzyme: Ligase Enzyme: Lipase Lipid Kinase Lipid phosphatase Enzyme: Lyase Membrane bound ligand Membrane transport protein Metallo protease Enzyme: Methyltransferase Motor protein Enzyme: Mutase MHC complex protein Neuraminidase Nuclear receptor Enzyme: Nucleotidyltransferase Enzyme: NADase Enzyme: Oxidase Enzyme: Oxidoreductase Enzyme: Oxygenase Peptide hormone Enzyme: Peroxidase Enzyme: Phosphatase,others Enzyme: Phosphodiesterase Enzyme: Phosphohydrolase Enzyme: Phospholipase Enzyme: Phosphorylase Enzyme: Phosphotransferase Enzyme: Phosphotriesterase Enzyme: Prenyltransferase Protease, unclassified Protease inhibitor Enzyme: Racemase Enzyme: Reductase Receptor serine/threonine kinase Receptor tyrosine kinase Receptor tyrosine phosphatase Regulatory/other subunit Reverse transcriptase Ribonuclease Ribonucleoprotein Ribosomal subunit Enzyme: Ribosyltransferase RNA binding protein RNA helicase RNA methyltransferase RNA polymerase Secreted polypeptide, miscellaneous Serine/threonine kinase Serine/threonine phosphatase Serine protease Enzyme: Sialyltransferase Storage protein Structural protein Enzyme: Sulphatase Enzyme: Sulphohydrolase Enzyme: Sulphotransferase Enzyme: Superoxide dismutase Enzyme: Synthetase T cell antigen receptor Enzyme: Thioesterase Enzyme: Topoisomerase Enzyme: Transaldolase Enzyme: Transaminase Transcription factor Transcription regulatory protein Enzyme: Transferase Enzyme: Transketolase Translation regulatory protein Enzyme: Translocase Transport/cargo protein Tyrosine kinase Tyrosine phosphatase Ubiquitin proteasome system protein Unclassified Voltage gated channel Water channel PTMs ADP Ribosylation Acetylation Alkylation Amidation Carboxylation Deglycosylation Dephosphorylation Disulfide Bridge Glutathionylation Glycation Glycosyl phosphatidyl inositol GPI Glycosylation Hydroxylation Methylation Myristoylation Neddylation Nitration Palmitoylation Phosphorylation Prenylation Proteolytic Cleavage S- Nitrosylation Sulfation Sumoylation Transglutamination Ubiquitination Cellular component list Cell projection Centrosome Cytoplasm Cytoplasmic vesicle Cytoskeleton Endoplasmic reticulum Endosome Extracellular Golgi apparatus Lysosome Microsome Mitochondrion Nucleolus Nucleus Peroxisome Plasma membrane Ribosome Sarcoplasmic reticulum Secretory granule Integral to membrane Motif list ARAM BOX 1 BOX 2 CAAX CC CRIB CXC CXXC GPI HKD HLH LZ NES NLS NPXY RGD SP WSXWS Expression list Please select a domain to browse: 35EXO A2M AAA ABH ACR ACTIN ADAP ADF ALDKR ALP AMY ANATO ANK ANX ARF ARFGAP ARM AT_hook Aamy_C AcidPPc Albumin B41 BAG BAR BASIC BBC BBOX BCL BH1 BH2 BH3 BH4 BIR BRCT BRIGHT BRK BRLZ BROMO BTB BTK Band 4.1 C1 C1Q C2 C345C C4 CALPAIN_III CALXB CARD CARP CASc CBS CH CHROMO CLH CNH CNMP CNX COLFI COLL CT CTLH CTNS CUB CUE CULL CYCLIN CYCLIN_C CYCLIN_N CYSPC CYSTATIN Cadherin DAGKC DAX DCX DEAD DEATH DED DEXDc DISINT DNAJ DNaseIc DSH DSL DSPC DSRM DUSP DYNC DYSFC Discoidin EF EGF EGFCA EGFL EGFLAM EH ENDO ERM ETS EXOIII Endonuclease F58C FBG FCH FERM FES FGF FH FH2 FHA FN1 FN2 FN3 FOLN FU FYRC FYVE FZ F_BOX G2F GAF GALP GAS2 GED GEL GHB GLA GPS GRAM GRAN GS GTP_EFTU GTP_EFTU_D2 GTP_EFTU_D3 GYF G_PATCH GuCyclase GuKinase H15 HAT HD_2 HDc HEAT HECT HELIC HHH HHH2 HIN HINT HMG HOLI HOX HR1 HRDC HRM HS1_rep HSF HX IB IBN_NT IBR IFABD IG IGC IGC2 IGFLMN IGV IL1 IL10 IL6 IL7 INS INTA INTB IPT IQ IRF ITAM I_Phosphatase Ig_LIKE JAB JH1 JH2 JH3 JH4 JH5 JH6 JH7 JMJC KAZAL KCchannel KELCH KH KISC KRAB KRINGLE KUNITZ Ktetra Ku78 L27 LAMB LAMG LAMGL LAMNT LCCL LDLA LDLRB LECTIN_C LER LH2 LIFOSM LIM LINK LISH LRR LRRTYP LU LYZ MADS MAGE MAM MARVEL MATH MBD MBT MCM MH1 MH2 MHCK MIF4G MIR ML MORN MUTSac MUTSd MYOSIN Methyltransf MoeAN MoeAc NDK NEBULIN NIDO NOTCH Neur_chan_LBD Neur_chan_memb OLF ORANGE P4HC PA28 PA28DA PA2c PAC PAH PAN PAS PAX PB1 PBD PBPE PCI PDGF PDZ PEST PGK PH PHB PHD PI3KA PI3KC PI3KC2 PIK PINT PIPKc PISC PKD PLCYc PLEC PLP PMP POU PP2A PP2C PPTC1 PQQ PROF PRP PRY PSET PSI PSN PTB PTBI PTN PTX PUA PUG PWI PWWP PX P_proprotein PkinA_anch Pumilio R3H RA RAB RAS RASGAP RBD REC REP RGS RHD RHO RHOD RHOGAP RHOGEF RING RNase RRM RWD RYDR RasGEF RasGEFN Runt S1 S4 SAA SAD SAM SAM_PNT SAND SANT SAP SAPA SAPB SCP SCY SEA SEC14 SEMA SERPIN SET SH2 SH3 SIS SKP1 SM SMC SOCS SOM SORB SPECTRIN SPRY SR START STI1 SULF SUSHI SYNUC S_100 S_T_Y_Kinase S_T_kinase Small_GTPase Sulfotransfer SynN TAFH TBOX TEA TFS TGC TGF TGFB THYRO TIR TLC TM TNF TNFR TPR TRAF TRANSGLUT TRANSTHYR TRNAA TRYPSIN TR_FER TSP1 TSP3 TSPN TSPc TUB TUBULIN TUDOR TY Trefoil Tyr_Kinase Tyr_Phos UBA UBC UBOX UBQ UBX UIM UTG VHP VHS VIT VPS9 VWA VWC VWD VWF WAP WD40 WH1 WH2 WIF WNT WW XPGI XTAL Peptidase, Tumor Necrosis Factor- Converting Enzyme (TACE) Phosphodiesterase PDE1 Phosphodiesterase PDE2 Phosphodiesterase PDE3 Phosphodiesterase PDE4 Phosphodiesterase PDE5 Phosphodiesterase PDE6 Phospholipase PLA2-I Phospholipase PLA2-II Phospholipase PLC Proteasome Protein Serine/Threonine Kinase, Ca2+/Calmodulin- Dep. II Protein Serine/Threonine Kinase, cdk1/Cyclin B Protein Serine/Threonine Kinase, cdk2/Cyclin A Protein Serine/Threonine Kinase, cdk5/p35 Protein Serine/Threonine Kinase, CHK1 - New Protein Serine/Threonine Kinase, CHK2 - New Protein Serine/Threonine Kinase, ERK1 Protein Serine/Threonine Kinase, ERK2 - Revised Protein Serine/Threonine Kinase, GSK-3 Protein Serine/Threonine Kinase, IKK-1 Protein Serine/Threonine Kinase, IKK-2 Protein Serine/Threonine Kinase, JNK11 - New Protein Serine/Threonine Kinase, JNK22 - New Protein Serine/Threonine Kinase, MEK1 - New Protein Serine/Threonine Kinase, p38 Protein Serine/Threonine Kinase, p38 Protein Serine/Threonine Kinase, p38 Protein Serine/Threonine Kinase, p38 Protein Serine/Threonine Kinase, p70S6K Protein Serine/Threonine Kinase, PDK1 - New Protein Serine/Threonine Kinase, PKA, Non- Selective Protein Serine/Threonine Kinase, PKB/Akt1 Protein Serine/Threonine Kinase, PKC, Non-Selective Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Kinase, PKC1 Protein Serine/Threonine Kinase, PKC2 Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Kinase, PKC Protein Serine/Threonine Phosphatase, Calcineurin, PP2B Protein Tyrosine Kinase, Abl Protein Tyrosine Kinase, BTK - New Protein Tyrosine Kinase, EGF Receptor Protein Tyrosine Kinase, Fes - New Protein Tyrosine Kinase, Flt-1 (VEGFR- 1) - New Protein Tyrosine Kinase, Flt-3 - New Protein Tyrosine Kinase, Fyn Protein Tyrosine Kinase, Insulin Receptor Protein Tyrosine Kinase, Lck Protein Tyrosine Kinase, Lyn A - New Protein Tyrosine Kinase, Lyn B - New Protein Tyrosine Kinase, p60c-SRC Protein Tyrosine Phosphatase, CD45 Protein Tyrosine Phosphatase, PTP1B Protein Tyrosine Phosphatase, PTP1C Protein Tyrosine Phosphatase, T-Cell Sphingomyelinase, Acid (A-SMase) Sphingomyelinase, Neutral (N- SMase) Steroid 5-Reductase Thioredoxin Reductase Thromboxane Synthase Tyrosine Hydroxylase Xanthine Oxidase 200510Adenosine A1Human$62.00 200610Adenosine A2AHuman$62.00 200720Adenosine A3 - Improved Human$62.00 203500Adrenergic 1, Non-SelectiveRat$25.00 203100Adrenergic 1ARat$37.00 203200Adrenergic 1BRat$37.00 203400Adrenergic 1DHuman$68.00 203900Adrenergic 2, Non- SelectiveRat$25.00 203620Adrenergic 2AHuman$62.00 203710Adrenergic 2BHuman$62.00 203800Adrenergic 2CHuman$62.00 204300Adrenergic , Non- SelectiveRat$37.00 204010Adrenergic 1Human$62.00 204110Adrenergic 2Human$62.00 204200Adrenergic 3Human$62.00 204600Aldosterone - New Rat$54.00 205000Anaphylatoxin C5aHuman$62.00 210020Angiotensin AT1Human$62.00 210110Angiotensin AT2Human$62.00 210700APJHuman$62.00 211000Atrial Natriuretic Factor (ANF)Guinea pig$37.00 226700Benzodiazepine, PeripheralRat$25.00 211600Bombesin BB1Human$62.00 211700Bombesin BB2Human$62.00 211800Bombesin BB3Human$62.00 211500Bombesin, Non- SelectiveRat$44.00 212510Bradykinin B1 - New Human$62.00 212610Bradykinin B2Human$62.00 213610CalcitoninHuman$62.00 214010Calcitonin Gene- Related Peptide CGRP1Human$62.00 214510Calcium Channel L-Type, BenzothiazepineRat$37.00 214600Calcium Channel L-Type, DihydropyridineRat$37.00 215000Calcium Channel L-Type, PhenylalkylamineRat$37.00 216000Calcium Channel N- TypeRat$44.00 217100Cannabinoid CB2Human$62.00 217500Chemokine CCR1Human$62.00 217550Chemokine CCR2BHuman$62.00 217650Chemokine CCR4Human$68.00 217700Chemokine CCR5Human$62.00 244300Chemokine CXCR1/2 (IL- 8, Non-Selective)Human$62.00 244500Chemokine CXCR2 (IL- 8B)Human$62.00 218010Cholecystokinin CCK1 (CCKA)Human$62.00 218120Cholecystokinin CCK2 (CCKB)Human$62.00 219100ColchicineRat$49.00 219150Corticotropin Releasing Factor CRF1Human$62.00 219500Dopamine D1Human$62.00 219600Dopamine D2LHuman$62.00 219700Dopamine D2SHuman$62.00 219800Dopamine D3Human$62.00 219900Dopamine D4.2Human$62.00 220000Dopamine D4.4Human$62.00 220100Dopamine D4.7Human$62.00 220200Dopamine D5Human$62.00 224010Endothelin ETAHuman$62.00 224110Endothelin ETBHuman$62.00 225500Epidermal Growth Factor (EGF)Human$62.00 226010Estrogen ERHuman$62.00 226050Estrogen ERHuman$62.00 226500GABAA, Agonist SiteRat$37.00 226600GABAA, Benzodiazepine, CentralRat$31.00 226810GABAA, Chloride Channel, TBOBRat$44.00 228510GABAB, Non- SelectiveRat$37.00 228700GABAB1BHuman$62.00 228600GABAB1AHuman$62.00 230000Gabapentin - New Rat$37.00 231510Galanin GAL1Human$62.00 231600Galanin GAL2Human$62.00 231700Glucagon-Like Peptide-1 (GLP- 1)Human$62.00 232010GlucocorticoidHuman$62.00 232600Glutamate, AMPARat$37.00 232700Glutamate, KainateRat$37.00 232810Glutamate, NMDA, AgonismRat$37.00 232910Glutamate, NMDA, GlycineRat$37.00 233000Glutamate, NMDA, PhencyclidineRat$37.00 234000Glutamate, NMDA, PolyamineRat$37.00 235010Glutamate, Non- SelectiveRat$37.00 239000Glycine, Strychnine- SensitiveRat$37.00 239300Growth Hormone Secretagogue (GHS, Ghrelin)Human$62.00 239610Histamine H1Human$62.00 239710Histamine H2Human$62.00 239810Histamine H3 - Improved Human$62.00 239900Histamine H4Human$62.00 241000Imidazoline I2, CentralRat$37.00 241100Imidazoline I2, PeripheralRat$37.00 242500Inositol Trisphosphate IP3Rat$49.00 243000InsulinRat$49.00 243510Interleukin IL- 1Mouse$49.00 243700Interleukin IL- 2Mouse$49.00 244100Interleukin IL- 6Human$62.00 250400LeptinMouse$49.00 250510Leukotriene, BLT (LTB4)Human$62.00 250460Leukotriene, Cysteinyl CysLT1 -  New Human$62.00 250480Leukotriene, Cysteinyl CysLT2 - New Human$62.00 251100Melanocortin MC1Human$62.00 251300Melanocortin MC3Human$62.00 251350Melanocortin MC4Human$62.00 251400Melanocortin MC5Human$62.00 251500Melatonin MT, Non- SelectiveChicken$49.00 251600Melatonin MT1 - New Human$62.00 252200MotilinHuman$62.00 252600Muscarinic M1Human$62.00 252700Muscarinic M2Human$62.00 252800Muscarinic M3Human$62.00 252900Muscarinic M4Human$62.00 253000Muscarinic M5Human$62.00 254000Muscarinic, Non- Selective, CentralRat$25.00 254500Muscarinic, Oxotremorine- MRat$37.00 226200N-Formyl Peptide Receptor-Like FPRL1 - New Human$62.00 256100Neuromedin U NMU1Human$62.00 256200Neuromedin U NMU2Human$62.00 257110Neuropeptide Y2Human$62.00 258010Neurotensin NT1Human$62.00 258000Neurotensin, Non- SelectiveMouse$49.00 258590Nicotinic AcetylcholineHuman$62.00 258630Nicotinic Acetylcholine, Bungarotoxin-Sensitive, Central - New Rat$44.00 258700Nicotinic Acetylcholine, Bungarotoxin- Sensitive, Neuromuscular - New Human$62.00 260110Opiate  (OP1, DOP)Human$62.00 260210Opiate  (OP2, KOP)Human$62.00 260410Opiate  (OP3, MOP)Human$62.00 260500Opiate, Non- SelectiveRat$25.00 260600Orphanin ORL1Human$62.00 264500Phorbol EsterMouse$37.00 265010Platelet Activating Factor (PAF)Human$62.00 265200Platelet- Derived Growth Factor (PDGF)Mouse$49.00 265500Potassium Channel [KA]Rat$41.00 265600Potassium Channel [KATP]Syrian hamster$37.00 265800Potassium Channel [SKCA]Rat$49.00 265900Potassium Channel HERGHuman$62.00 268000ProgesteroneBovine$49.00 268020Progesterone PR- BHuman$62.00 268050Prostanoid DP - New Human$62.00 285510Prostanoid, Thromboxane A2 (TP)Human$62.00 268700Purinergic P2XRabbit$37.00 268810Purinergic P2YRat$37.00 270000RolipramRat$49.00 271000Serotonin (5- Hydroxytryptamine) 5-HT1, Non- SelectiveRat$37.00 271110Serotonin (5- Hydroxytryptamine) 5- HT1AHuman$62.00 271200Serotonin (5- Hydroxytryptamine) 5- HT1BRat$44.00 271600Serotonin (5- Hydroxytryptamine) 5-HT2, Non- SelectiveRat$25.00 271650Serotonin (5- Hydroxytryptamine) 5- HT2AHuman$62.00 271700Serotonin (5- Hydroxytryptamine) 5- HT2BHuman$62.00 271800Serotonin (5- Hydroxytryptamine) 5- HT2CHuman$62.00 271910Serotonin (5- Hydroxytryptamine) 5- HT3Human$62.00 272000Serotonin (5- Hydroxytryptamine) 5- HT4Guinea pig$37.00 272100Serotonin (5- Hydroxytryptamine) 5- HT5AHuman$62.00 272200Serotonin (5- Hydroxytryptamine) 5- HT6Human$62.00 272320Serotonin (5- Hydroxytryptamine) 5- HT7Human$62.00 278300Sigma, Non- SelectiveGuinea pig$37.00 278110Sigma 1Human$62.00 278200Sigma 2Rat$37.00 279510Sodium Channel, Site 2Rat$49.00 282510Somatostatin sst1Human$62.00 282700Somatostatin sst2Human$62.00 282530Somatostatin sst3Human$62.00 282900Somatostatin sst4Human$62.00 283000Somatostatin sst5Human$62.00 255510Tachykinin NK1Human$62.00 255600Tachykinin NK2Human$62.00 285010TestosteroneRat$49.00 285900Thyroid Hormone - New Rat$37.00 286000Thyrotropin Releasing Hormone (TRH)Rat$49.00 286200Transforming Growth Factor- (TGF-)Mouse$49.00 202000Transporter, AdenosineGuinea pig$36.00 219000Transporter, CholineRat$36.00 220320Transporter, Dopamine (DAT)Human$62.00 226400Transporter, GABARat$36.00 239100Transporter, GlycineRat$41.00 252010Transporter, MonoamineRabbit$54.00 204410Transporter, Norepinephrine (NET)Human$62.00 274020Transporter, Serotonin (5- Hydroxytryptamine) (SERT)Human$62.00 286510Tumor Necrosis Factor (TNF), Non- SelectiveHuman$62.00 286700Urotensin IIHuman$62.00 286810Vanilloid - New Rat$54.00 286900Vascular Endothelial Growth Factor (VEGF)Human$62.00 287010Vasoactive Intestinal Peptide VIP1Human$62.00 287520Vasopressin V1AHuman$62.00 287560Vasopressin V1BHuman$62.00 287610Vasopressin V2 - Revised Human$62.00 288000Vitamin D3Human$62.00 104010AcetylcholinesteraseHuman$53.00 112000Carbonic AnhydraseHuman$92.00 113000Choline AcetyltransferaseHuman$92.00 116020Cyclooxygenase COX- 1Human$113.00 118010Cyclooxygenase COX- 2Human$113.00 118040CYP450, 19Human$62.00 118050CYP450, 1A2Human$62.00 118070CYP450, 2C19Human$62.00 118060CYP450, 2C9Human$62.00 118080CYP450, 2D6Human$62.00 118090CYP450, 3A4Human$62.00 133000LipaseHuman$92.00 137010Lipoxygenase 12-LO - New Human$113.00 136010Lipoxygenase 5- LOHuman$113.00 140010Monoamine Oxidase MAO- A - Improved Human$62.00 140120Monoamine Oxidase MAO- B - Improved Human$62.00 121000MyeloperoxidaseHuman$92.00 108010Peptidase, Calpain- 1Human$92.00 163000Peptidase, Caspase 1Human$92.00 163100Peptidase, Caspase 2Human$53.00 163200Peptidase, Caspase 3Human$53.00 163240Peptidase, Caspase 4Human$113.00 163280Peptidase, Caspase 5Human$113.00 163300Peptidase, Caspase 6Human$53.00 163400Peptidase, Caspase 7Human$53.00 163500Peptidase, Caspase 8Human$53.00 163600Peptidase, Caspase 9Human$92.00 163700Peptidase, Caspase 10Human$53.00 112250Peptidase, Cathepsin BHuman$92.00 112350Peptidase, Cathepsin DHuman$92.00 112400Peptidase, Cathepsin EHuman$92.00 112510Peptidase, Cathepsin GHuman$92.00 112550Peptidase, Cathepsin HHuman$92.00 112650Peptidase, Cathepsin LHuman$92.00 112750Peptidase, Cathepsin SHuman$92.00 112800Peptidase, Cathepsin VHuman$92.00 112900Peptidase, Cathepsin Z - New Human$92.00 113300Peptidase, ChymaseHuman$113.00 113400Peptidase, ChymotrypsinHuman$113.00 163950Peptidase, Endothelin Converting Enzyme-1 (ECE-1) - New Human$83.00 113500Peptidase, Factor VIIaHuman$113.00 113600Peptidase, Factor XaHuman$113.00 113800Peptidase, Kallikrein, PlasmaHuman$50.00 166000Peptidase, Leukocyte ElastaseHuman$92.00 114110Peptidase, Matrix Metalloproteinase- 1 (MMP- 1)Human$99.00 114210Peptidase, Matrix Metalloproteinase-2 (MMP- 2)Human$99.00 114310Peptidase, Matrix Metalloproteinase-3 (MMP- 3)Human$99.00 114710Peptidase, Matrix Metalloproteinase-7 (MMP- 7)Human$99.00 114800Peptidase, Matrix Metalloproteinase-8 (MMP- 8)Human$99.00 114910Peptidase, Matrix Metalloproteinase-9 (MMP- 9)Human$99.00 115200Peptidase, Matrix Metalloproteinase-12 (MMP-12) - New Human$99.00 115300Peptidase, Matrix Metalloproteinase-13 (MMP- 13)Human$99.00 115400Peptidase, Matrix Metalloproteinase-14 (MMP- 14)Human$99.00 164000Peptidase, Metalloproteinase, Neutral EndopeptidaseHuman$53.00 164500Peptidase, PlasminHuman$113.00 164600Peptidase, ReninHuman$113.00 165000Peptidase, ThrombinHuman$113.00 165050Peptidase, Tissue Plasminogen Activator (tPA)Human$113.00 165100Peptidase, TrypsinHuman$113.00 165200Peptidase, TryptaseHuman$113.00 166500Peptidase, Tumor Necrosis Factor-  Converting Enzyme (TACE)Human$113.00 148000Phosphodiesterase PDE2Human$62.00 152000Phosphodiesterase PDE3Human$62.00 154000Phosphodiesterase PDE4Human$62.00 156000Phosphodiesterase PDE5Human$62.00 167000ProteasomeHuman$92.00 167100Protein Serine/Threonine Kinase, Aurora A - New Human$113.00 168100Protein Serine/Threonine Kinase, cdk1/Cyclin BHuman$92.00 168200Protein Serine/Threonine Kinase, cdk2/Cyclin AHuman$92.00 168500Protein Serine/Threonine Kinase, cdk5/p35Human$124.00 168600Protein Serine/Threonine Kinase, CHK1 - New Human$113.00 168650Protein Serine/Threonine Kinase, CHK2 - New Human$113.00 168800Protein Serine/Threonine Kinase, CSNK1 - New Human$113.00 169000Protein Serine/Threonine Kinase, CSNK1D -  New Human$113.00 169050Protein Serine/Threonine Kinase, CSNK2 - New Human$113.00 171000Protein Serine/Threonine Kinase, ERK1Human$113.00 176500Protein Serine/Threonine Kinase, GSK-3Human$113.00 176200Protein Serine/Threonine Kinase, IKK-1Human$140.00 176300Protein Serine/Threonine Kinase, IKK-2Human$140.00 171200Protein Serine/Threonine Kinase, JNK11 - New Human$113.00 171300Protein Serine/Threonine Kinase, JNK22 - New Human$113.00 171350Protein Serine/Threonine Kinase, JNK3 - New Human$92.00 171380Protein Serine/Threonine Kinase, MAPKAPK5 (PRAK) - New Human$113.00 176110Protein Serine/Threonine Kinase, MEK1 - New Human$92.00 176600Protein Serine/Threonine Kinase, p38Human$113.00 176650Protein Serine/Threonine Kinase, p38Human$113.00 176750Protein Serine/Threonine Kinase, p38Human$113.00 176700Protein Serine/Threonine Kinase, p38Human$113.00 176900Protein Serine/Threonine Kinase, p70S6KHuman$113.00 171400Protein Serine/Threonine Kinase, PDK1 - New Human$113.00 171420Protein Serine/Threonine Kinase, PIM1 - New Human$113.00 177500Protein Serine/Threonine Kinase, PKB/Akt1Human$113.00 180010Protein Serine/Threonine Kinase, PKCHuman$99.00 183000Protein Serine/Threonine Kinase, PKC1Human$99.00 183500Protein Serine/Threonine Kinase, PKC2Human$99.00 184200Protein Serine/Threonine Kinase, PKCHuman$99.00 184400Protein Serine/Threonine Kinase, PKCHuman$113.00 184600Protein Serine/Threonine Kinase, PKCHuman$113.00 184010Protein Serine/Threonine Kinase, PKCHuman$99.00 185000Protein Serine/Threonine Kinase, PKCHuman$113.00 185200Protein Serine/Threonine Kinase, PKCHuman$113.00 171480Protein Serine/Threonine Kinase, PKG1 - New Human$113.00 171520Protein Serine/Threonine Kinase, ROCK1 -  New Human$113.00 171550Protein Serine/Threonine Kinase, ROCK2 - New Human$113.00 188010Protein Serine/Threonine Phosphatase, Calcineurin, PP2BHuman$113.00 171630Protein Tyrosine Kinase, BLK - New Human$92.00 171660Protein Tyrosine Kinase, BMX -  New Human$92.00 171700Protein Tyrosine Kinase, BTK - New Human$92.00 170010Protein Tyrosine Kinase, EGF ReceptorHuman$92.00 171750Protein Tyrosine Kinase, Fes - New Human$92.00 171770Protein Tyrosine Kinase, FGFR4 - New Human$92.00 171800Protein Tyrosine Kinase, Flt-1 (VEGFR-1) - New Human$92.00 171850Protein Tyrosine Kinase, Flt-3 - New Human$92.00 174010Protein Tyrosine Kinase, HER2 Receptor - New Human$92.00 175000Protein Tyrosine Kinase, Insulin ReceptorHuman$92.00 176010Protein Tyrosine Kinase, LckHuman$92.00 176050Protein Tyrosine Kinase, Lyn A - New Human$113.00 176070Protein Tyrosine Kinase, Lyn B - New Human$113.00 175030Protein Tyrosine Kinase, MET - New Human$92.00 176800Protein Tyrosine Kinase, p60c- SRCHuman$92.00 175060Protein Tyrosine Kinase, PTK2B - New Human$92.00 175080Protein Tyrosine Kinase, YES - New Human$92.00 190000Protein Tyrosine Phosphatase, CD45Human$113.00 192000Protein Tyrosine Phosphatase, PTP1BHuman$92.00 192200Protein Tyrosine Phosphatase, PTP1CHuman$92.00 192900Protein Tyrosine Phosphatase, PTPN11 (SHP-2) - New Human$92.00 193000Protein Tyrosine Phosphatase, T- CellHuman$92.00 141400Sphingomyelinase, Acid (A- SMase)Human$92.00 194010Thromboxane SynthaseHuman$124.00 123000- D-GlucosidaseRice (2) 123500- GlucuronidaseBovine (2) 104010AcetylcholinesteraseHuman (2) 107500ATPase, H+/K+Rabbit (2) 107700ATPase, Na+/K+Dog (2) 112000Carbonic AnhydraseHuman (2) 112100Carnitine Palmitoyltransferase-1 (CPT-1)Rat (2) 112200Catechol-O- Methyltransferase (COMT)Porcine (2) 113000Choline AcetyltransferaseHuman (2) 116020Cyclooxygenase COX- 1Human (2) 118010Cyclooxygenase COX- 2Human (2) 118040CYP450, 19Human (2) 118050CYP450, 1A2Human (2) 118070CYP450, 2C19Human (2) 118060CYP450, 2C9Human (2) 118080CYP450, 2D6Human (2) 118090CYP450, 3A4Human (2) 193500Free Radical Scavenger, SOD MimeticBovine (2) 120010Fructose-1,6- Bisphosphatase (FBPase)Rabbit (2) 132000Leukotriene LTC4 SynthaseGuinea pig (2) 133000LipaseHuman (2) 134000Lipid PeroxidaseGuinea pig (2) 138000Lipoxygenase 15- LORabbit (2) 140010Monoamine Oxidase MAO-AHuman (2) 140120Monoamine Oxidase MAO-  BHuman (2) 121000MyeloperoxidaseHuman (2) 143000Nitric Oxide Synthase, Endothelial (eNOS)Bovine (2) 144000Nitric Oxide Synthase, Inducible (iNOS)Mouse (2) 142000Nitric Oxide Synthase, Neuronal (nNOS)Rat (2) 107300Peptidase, Angiotensin Converting EnzymeRabbit (2) 108010Peptidase, Calpain-1Human (2) 163000Peptidase, Caspase 1Human (2) 112250Peptidase, Cathepsin BHuman (2) 112350Peptidase, Cathepsin DHuman (2) 113400Peptidase, ChymotrypsinHuman (2) 163900Peptidase, Dipeptidyl Peptidase IV (DPP IV)Porcine (2) 113500Peptidase, Factor VIIaHuman (2) 113600Peptidase, Factor XaHuman (2) 166000Peptidase, Leukocyte ElastaseHuman (2) 114110Peptidase, Matrix Metalloproteinase-1 (MMP- 1)Human (2) 114210Peptidase, Matrix Metalloproteinase-2 (MMP- 2)Human (2) 114310Peptidase, Matrix Metalloproteinase-3 (MMP- 3)Human (2) 114800Peptidase, Matrix Metalloproteinase-8 (MMP- 8)Human (2) 114910Peptidase, Matrix Metalloproteinase-9 (MMP- 9)Human (2) 164000Peptidase, Metalloproteinase, Neutral EndopeptidaseHuman (2) 164600Peptidase, ReninHuman (2) 165000Peptidase, ThrombinHuman (2) 165050Peptidase, Tissue Plasminogen Activator (tPA)Human (2) 165100Peptidase, TrypsinHuman (2) 166500Peptidase, Tumor Necrosis Factor- Converting Enzyme (TACE)Human (2) 152000Phosphodiesterase PDE3Human (2) 154000Phosphodiesterase PDE4Human (2) 156000Phosphodiesterase PDE5Human (2) 156100Phosphodiesterase PDE6Bovine (2) 160100Phospholipase PLA2- IICrotalus atrox (2) 167000ProteasomeHuman (2) 168000Protein Serine/Threonine Kinase, Ca2+/Calmodulin-Dep. IIRat (2) 168100Protein Serine/Threonine Kinase, cdk1/Cyclin BHuman (2) 171000Protein Serine/Threonine Kinase, ERK1Human (2) 176200Protein Serine/Threonine Kinase, IKK-1Human (2) 176300Protein Serine/Threonine Kinase, IKK-2Human (2) 176110Protein Serine/Threonine Kinase, MEK1Human (2) 176600Protein Serine/Threonine Kinase, p38Human (2) 177500Protein Serine/Threonine Kinase, PKB/Akt1Human (2) 180010Protein Serine/Threonine Kinase, PKCHuman (2) 183000Protein Serine/Threonine Kinase, PKC1Human (2) 188010Protein Serine/Threonine Phosphatase, Calcineurin, PP2BHuman (2) 171600Protein Tyrosine Kinase, AblMouse (2) 170010Protein Tyrosine Kinase, EGF ReceptorHuman (2) 172010Protein Tyrosine Kinase, FynBovine (2) 175000Protein Tyrosine Kinase, Insulin ReceptorHuman (2) 176010Protein Tyrosine Kinase, LckHuman (2) 176800Protein Tyrosine Kinase, p60c-SRCHuman (2) 192000Protein Tyrosine Phosphatase, PTP1BHuman (2) 141400Sphingomyelinase, Acid (A- SMase)Human (2) 123000-D- GlucosidaseRice (2) 123500- GlucuronidaseBovine (2) 104010AcetylcholinesteraseHuman (2) 107500ATPase, H+/K+Rabbit (2) 107700ATPase, Na+/K+Dog (2) 112000Carbonic AnhydraseHuman (2) 112100Carnitine Palmitoyltransferase-1 (CPT-1)Rat (2) 112200Catechol-O- Methyltransferase (COMT)Porcine (2) 113000Choline AcetyltransferaseHuman (2) 116020Cyclooxygenase COX- 1Human (2) 118010Cyclooxygenase COX- 2Human (2) 118040CYP450, 19Human (2) 118050CYP450, 1A2Human (2) 118070CYP450, 2C19Human (2) 118060CYP450, 2C9Human (2) 118080CYP450, 2D6Human (2) 118090CYP450, 3A4Human (2) 193500Free Radical Scavenger, SOD MimeticBovine (2) 120010Fructose-1,6- Bisphosphatase (FBPase)Rabbit (2) 132000Leukotriene LTC4 SynthaseGuinea pig (2) 133000LipaseHuman (2) 134000Lipid PeroxidaseGuinea pig (2) 138000Lipoxygenase 15- LORabbit (2) 140010Monoamine Oxidase MAO-AHuman (2) 140120Monoamine Oxidase MAO-  BHuman (2) 121000MyeloperoxidaseHuman (2) 143000Nitric Oxide Synthase, Endothelial (eNOS)Bovine (2) 144000Nitric Oxide Synthase, Inducible (iNOS)Mouse (2) 142000Nitric Oxide Synthase, Neuronal (nNOS)Rat (2) 107300Peptidase, Angiotensin Converting EnzymeRabbit (2) 108010Peptidase, Calpain- 1Human (2) 163000Peptidase, Caspase 1Human (2) 112250Peptidase, Cathepsin BHuman (2) 112350Peptidase, Cathepsin DHuman (2) 113400Peptidase, ChymotrypsinHuman (2) 163900Peptidase, Dipeptidyl Peptidase IV (DPP IV)Porcine (2) 113500Peptidase, Factor VIIaHuman (2) 113600Peptidase, Factor XaHuman (2) 166000Peptidase, Leukocyte ElastaseHuman (2) 114110Peptidase, Matrix Metalloproteinase-1 (MMP- 1)Human (2) 114210Peptidase, Matrix Metalloproteinase-2 (MMP- 2)Human (2) 114310Peptidase, Matrix Metalloproteinase-3 (MMP- 3)Human (2) 114800Peptidase, Matrix Metalloproteinase-8 (MMP- 8)Human (2) 114910Peptidase, Matrix Metalloproteinase-9 (MMP- 9)Human (2) 164000Peptidase, Metalloproteinase, Neutral EndopeptidaseHuman (2) 164600Peptidase, ReninHuman (2) 165000Peptidase, ThrombinHuman (2) 165050Peptidase, Tissue Plasminogen Activator (tPA)Human (2) 165100Peptidase, TrypsinHuman (2) 166500Peptidase, Tumor Necrosis Factor- Converting Enzyme (TACE)Human (2) 152000Phosphodiesterase PDE3Human (2) 154000Phosphodiesterase PDE4Human (2) 156000Phosphodiesterase PDE5Human (2) 156100Phosphodiesterase PDE6Bovine (2) 160100Phospholipase PLA2- IICrotalus atrox (2) 167000ProteasomeHuman (2) 168000Protein Serine/Threonine Kinase, Ca2+/Calmodulin-Dep. IIRat (2) 168100Protein Serine/Threonine Kinase, cdk1/Cyclin BHuman (2) 171000Protein Serine/Threonine Kinase, ERK1Human (2) 176200Protein Serine/Threonine Kinase, IKK-1Human (2) 176300Protein Serine/Threonine Kinase, IKK-2Human (2) 176110Protein Serine/Threonine Kinase, MEK1Human (2) 176600Protein Serine/Threonine Kinase, p38Human (2) 177500Protein Serine/Threonine Kinase, PKB/Akt1Human (2) 180010Protein Serine/Threonine Kinase, PKCHuman (2) 183000Protein Serine/Threonine Kinase, PKC1Human (2) 188010Protein Serine/Threonine Phosphatase, Calcineurin, PP2BHuman (2) 171600Protein Tyrosine Kinase, AblMouse (2) 170010Protein Tyrosine Kinase, EGF ReceptorHuman (2) 172010Protein Tyrosine Kinase, FynBovine (2) 175000Protein Tyrosine Kinase, Insulin ReceptorHuman (2) 176010Protein Tyrosine Kinase, LckHuman (2) 176800Protein Tyrosine Kinase, p60c-SRCHuman (2) 192000Protein Tyrosine Phosphatase, PTP1BHuman (2) 141400Sphingomyelinase, Acid (A- SMase)Human (2) Affinity, free energy calculation, validated, HTS and combinatorial chemistry/high- speed synthesis (HSS), Van der Waals, van der Waals, scoring function, flexible ligand, rigid protein, breakthrow, quantum algorithms, quantum computer, outsource, opportunity, outsourcing, docking, ligand docking, subcontract, medical, Research and Development, R&D, Preclinical, Chemistry, Disease, СПИД, Новые лекарства, Интеграза, Белок-мишень, Ингибитор, Лиганд, Докинг, Ингибирование, Энергия связывания, технологии, химия, биология, медицина, qBuilder, qOptimal, Force Fields, Pipeline, DFT, Hartree-Fock, protein folding, X-ray spectroscopy, 3-D structure, 3D protein structure, proprietary computational technology, Complexity Analysis, supercomputer, quantum information, polynomial, quantum methods, cutting-edge technology, build new leads, proprietary tools for structure based drug design, computer application tool, The accurate calculation of binding free energy, in-house, tools for the docking, screening, and lead optimization procedures, protein- ligand complex, computational algorithms, linear scaling, drug development, Linux cluster as a C++ program, parameters of intermolecular interactions, computer science news events, new small-molecule drug candidates for kinases, receptors and ion channels, structure- based design techniques, binding free energy-- electrostatic contribution, Van der Waals energy, hydrophobic interactions, and entropic free energy contribution, FDA, "large" molecules, minimum binding energy, the ligand structure, and the coordinates of the active site of the protein. The output data given are the coordinates of the docked ligand and the minimum value of the binding free energy, hit identification, seed structure, coordinates of the docked ligand and the minimum value of the binding free energy, focused libraries, ADME, ADMET, X-ray spectroscopy to model the 3-D structures of the majority of G- coupled receptors, cost, human immunodeficiency virus, Joint United Nations Programme on HIV/AIDS, Integration of viral DNA into the host chromosome, HIV replication cycle, viral integrase protein, which, along with protease and reverse transcriptase, is one of three enzymes encoded by HIV, binding affinities of not less than about 10-8 mol/l, preclinical and clinical trials, Target identification, Target prioritization/validation, Toxicology, Food and Drug Administration, PhRMA, International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceutical Products (ICH), EU's Committee for the Proprietary Medicinal Products (CPMP) and the Japanese Ministry of Health and Welfare (MHW), EMEA, The Federal Food, Drug, and Cosmetic Act, Investigational New Drug (IND) Application Process, Animal Pharmacology and Toxicology Studies, Manufacturing, Clinical Protocols and Investigator Information, CDER, medicines, granting, Committee for Proprietary Medicinal Products (CPMP), EU Commission, The Pharmaceutical Affairs Law (PAL), safety measures, Japanese Drug Organization and the Evaluation Centre, marketable drugs, VS, Reduced rates of drug failure, Speed of Discovery, random screening of compound collections, smart screening, scoring method, business development, creation of focused or diverse chemical libraries, and searching existing chemical databases, royalty, finance, biological markers—proteins, pharmacodynamic, consumer market, intellectual property, patent, investors, venture capital, genomics and the mapping of the human genome, reduce failure rates