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Nuclear receptors are a class of intracellular receptors. They are located inside
the cell rather
than on its outer cell membrane. The ligands that bind to nuclear receptors are often lipophilic
hormones like steroid hormones. Practically all intracellular receptors are transcription factors.
When activated they migrate to the cell nucleus and bind to DNA and stimulate or suppress
gene transcription. Many receptors require dimerisation (binding either another receptor of the
same type, a different type or even a different protein). Some intracellular receptors also
appear to interact with other signal transduction mechanisms.
(source: Wikipedia)
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Invitrogen
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Nuclear Receptors
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FRET NR coactivator assays
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DiscoverX
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http://www.discoverx.com/products.php?p=13
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University of Georgetown
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Nuclear receptor resource
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PPAR resource pages
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http://ppar.cas.psu.edu/
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Nuclear Receptor
reource
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http://nrr.georgetown.edu/NRR/NRR1.html
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Thyroid hormone-like receptors HNF3-like receptors Estrogen-like receptors PPAR PPAR-
alpha PPAR- gamma LXR FXR
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